Gene–exercise interaction on brain health in children with overweight/obesity: the ActiveBrains randomized controlled trial
Year: 2023
Type: article
Abstract: Interindividual differences have been reported in brain health-related outcomes in response to exercise interventions in adults, which could be partially explained by genetic background differences. However, the role of genetic polymorphisms on brain health-related outcomes in response to exercise interventions remains unexplored in pediatric population. The current study in children with overweight/obesity showed that a genetic score composed of six brain health-related polymorphisms ( BDNF, CREB1, NTRK2, COMT, and APOE) regulated the exercise-induced response on several brain health outcomes, yet mainly and more consistently on cognitive flexibility.
Source: Journal of Applied Physiology
Institutions: Universidad de Granada, University of California, Irvine, Instituto de Salud Carlos III, Instituto de Investigación Biosanitaria de Granada, Institut de Recerca Biomèdica Catalunya Sud, Hospital Universitari Joan XXIII de Tarragona, Universidad Loyola Andalucía, Universidad Pública de Navarra (UPNA), Navarre Institute of Health Research, Karolinska University Hospital, Karolinska Institutet, University of Jyväskylä
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: European Commission, Consejería de Economía, Innovación, Ciencia y Empleo, Junta de Andalucía, Ministerio de Economía y Competitividad, Ministerio de Ciencia e Innovación, Universidad de Granada, National Institutes of Health, Instituto de Salud Carlos III, European Regional Development Fund, National Center for Advancing Translational Sciences
Awards: G1147370373, G1360419368, G1474068909, G1526658588, G1538615185, G1658123240, G174186380, G204047516, G2273317491, G2993404830, G4107514691, G4504565901, G5827691143, G5982725795, G643876076, G6786620779, G7304177560, Transforming Exercise Testing and Physical Activity Assessment in Children: New Approaches to Advance Clinical Translational Research in Child Health, G8025585172, G8363488173, G8704277885
OpenAlex ID: W4385897397