Work

Systematic investigation of allelic regulatory activity of schizophrenia-associated common variant

Year: 2023

Type: article

Abstract: README for SCZ MPRA created by [email protected] 08/07/2023 BEFORE RUNNING SCRIPTS Download files files from GEO (GSE211045) Git clone or download our files and scripts to your local/virtual environment. Modify config_scz.yml file within files/ folder (You only need to modify first three variables). Modify script_dir: to identify where the scripts/ from github are stored. Modify scz_file_foldername: to identify where the files from GEO are stored. Modify output_file_dir: to identify the location of the mpra result. RUNNING SCRIPTS Generate MPRA results: run generate_mpra_result_from_count_fastq if you want to generate MPRA results from FASTQ files run generate_mpra_result_from_count_matrix if you want to generate MPRA results from DNA/RNA count files (these files are preprocessed, merged, and modified FASTQ files). MPRA result will be created within the folder you specificied above (output_file_dir:)

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.8221492

Authors: McAfee, Jessica, Lee, Sool, Jiseok Lee, Bell, Jessica, Krupa, Oleh, Davis, Jessica, Insigne, Kimberly, Bond, Marielle, Nanxiang Zhao, Boyle, Alan, Phanstiel, Douglas, Love, Michael, Stein, Jason, W Brad Ruzicka, Davila-Velderrain, Jose, Sriram Kosuri, Hyejung Won

Institutions: University of North Carolina at Chapel Hill, University of California, Los Angeles, University of Michigan, Harvard University, Human Technopole

Language: English

Topic: Genomics and Chromatin Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4385963531

FWCI:

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