Novel and highly reliable leak check tests for drop‐ and external pressure‐type cell‐free and concentrated ascites reinfusion therapy
Year: 2023
Type: article
Abstract: INTRODUCTION: For safe management of cell-free and concentrated ascites reinfusion therapy (CART), a highly reliable leak test for detecting ascites filter damage is essential. However, such a test has not been established for drop-type CART. METHODS: We devised two novel leak tests for drop- and external pressure-type CART, manual or pump pressurization methods, using high-pressure loading and pressure monitoring, and investigated their reliability. RESULTS: Both methods could easily load and maintain sufficiently high pressure (>400 Torr) on the hollow fibers for 2 min. No result deviation was noted between different operators. The pressure drops in both methods were identical and significantly lower than those in the leak test using a special CART machine, the e-CART. CONCLUSION: The reliability of our revised leak test is equivalent to that of the automatic leak test of e-CART. These highly reliable leak tests may contribute to safety in patients undergoing drop- and external pressure-type CART.
Authors: Yasuko Kobayashi, Nana Ozawa, Tamami Yoshida, Takashi Minowa, Yuki Michinaga, Keita Inui, Koji Hashimoto, Yuji Kamijo
Institutions: Shinshu University Hospital, Shinshu University
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,350
OpenAlex ID: W4385969080