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Spatial multimodal analysis of transcriptomes and metabolomes in tissues

Year: 2023
Type: article
Abstract: We present a spatial omics approach that combines histology, mass spectrometry imaging and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular-weight metabolites across tissue regions. The workflow is compatible with commercially available Visium glass slides. We demonstrate the potential of our method using mouse and human brain samples in the context of dopamine and Parkinson's disease.
DOI: 10.1038/s41587-023-01937-y
Authors: Marco Vicari, Reza Mirzazadeh, Anna Nilsson, Reza Shariatgorji, Patrik Bjärterot, Ludvig Larsson, Hower Lee, Mats Nilsson, Julia Foyer, Markus Ekvall, Paulo Czarnewski, Xiaoqun Zhang, Per Svenningsson, Lukas Käll, Per E. Andrén, Joakim Lundeberg
Institutions: Science for Life Laboratory, KTH Royal Institute of Technology, Uppsala University, Stockholm University, Karolinska Institutet, King's College London
Language: English
Open Access status: hybrid
Estimated APC paid: $11,690
Funders: Leona M. and Harry B. Helmsley Charitable Trust, Stiftelsen för Strategisk Forskning, Hjärnfonden, Knut och Alice Wallenbergs Stiftelse, Kungliga Tekniska Högskolan, Vetenskapsrådet, Science for Life Laboratory, Horizon 2020 Framework Programme
Awards: Enabling Targeted Spatial Omics for Research and Diagnostics, Spatial Omics Enable Improved Pathophysiology-based Diagnosis of Parkinson´s Disease Dementia and Dementia with Lewy Bodies, G495187929, G6207132435, G7533661546, Exploration of neurochemical changes associated with L-DOPA-induced dyskinesia in Parkinson´s disease by mass spectrometry imaging, Integration of spatially resolved multiomics
OpenAlex ID: W4386415960
FWCI: 14.28
Cites: 31
Cited by: 191
Related to: 10