Synthesis and biological evaluation of [1,2,3]triazolo[4',5':3,4]pyrrolo[1,2-a] indoles: one-pot reaction under microwave irradiation
Year: 2023
Type: article
Abstract: rn rn rn rn rn rn rn rn rn rn rn rn rn rn rn rn rn rnrn rnrn rn rnThe synthesis and structural determination of several new fused [1,2,3]triazolo-[4',5':3,4]pyrrolo-[1,2-a]indole derivatives (4a-4p) utilising 1HNMR, 13CNMR, and mass spectrum analysis were discussed. The in vitro antibacterial activity of the compounds (4a-4p) against three gramme positive bacterial strains such as B.subtilis, S.aureus, and S.epidermidis revealed that the compounds 4h, 4j, and 4k demonstrated greater activity than the remaining compounds. Compounds 4d, 4i, and 4l had comparable activity to the standard. The antioxidant activity screening findings show that compounds 4c, 4d, and 4j have higher activity than conventional Trolox. Compounds 4b, 4h, 4k, and 4l have high activity, whereas the remaining compounds have moderate to low activity.
Source: Organic Communications
Authors: Abhilasha Dubba, Koppula Shiva Kumar
Institution: GITAM University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4386493607