Work

Low-Molecular-Weight Collagens (Post Collagen®) Produced via Fermentation With Supernatant of Lacticaseibacillus rhamnosus IDCC 3201 and Their Biological Activities

Year: 2023

Type: article

Abstract: Supplementing with low-molecular-weight collagen peptides (LMWCPs) contributes to counteracting signs of aging and improving skin hydration.In this study, a method for producing LMWCPs (Post Collagen ® ) from raw collagen material was developed as follows: 1) cultivating Lacticaseibacillus rhamnosus IDCC 3201, 2) and collecting the liquid part above the sediment, 3) fermenting the collected liquid (2,500 L) with raw collagen material (1,000 kg) and 4) performing spray-drying.Analysis using gel permeation chromatography confirmed that the raw collagen material had broken down into LMWCPs.Additionally, these fermented collagen peptides (FCP, Post Collagen ® ) displayed antimicrobial activity against 4 major bacteria responsible for causing gastroenteritis.In terms of their potential benefits, treating normal human dermal fibroblasts with 80 mg/mL of FCP significantly increased the production of type I procollagen and stimulated the up-regulation of the hyaluronan synthase 2 gene.Therefore, these findings support that the supernatant of L. rhamnosus IDCC 3201 culture could offer various health benefits of the collagens from of various sources by providing LMWCPs as multifunctional dietary components.

Source: Food Supplements and Biomaterials for Health

DOI: 10.52361/fsbh.2023.3.e16