Matching-adjusted Indirect Comparison (MAIC) of Tralokinumab Versus Dupilumab for the Treatment of Moderate to Severe Adult Atopic Dermatitis
Year: 2023
Type: article
Abstract: Objective: Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disease.Both tralokinumab and dupilumab have been recommended in the European Guideline for the treatment of adult patients with severe AD.In Korea, dupilumab has been approved for patients with moderate to severe AD, and reimbursed for those with severe AD.Since there is no clinical trial directly comparing tralokinumab and dupilumab, we conducted indirect comparison to assess the clinical usefulness in patients with AD.Methods: We selected clinical trials for indirect comparison through a systematic literature review.Individual patient data were available for the tralokinumab clinical trial, and aggregated data were available for the dupilumab clinical trial.Therefore, we employed the Matching-Adjusted Indirect Comparison (MAIC) method.The treatment efficacy was assessed based on whether patients achieved a 75% reduction on the Eczema Area and Severity Index (EASI 75) after drug administration.Results: The difference in the proportion of patients achieving EASI 75 between tralokinumab and dupilumab was 4.7% (95% CI: -7.9 to 17.3).Considering the non-inferiority margin for the EASI 75 achievement rate is -10%, tralokinumab is deemed non-inferior to dupilumab as the lower bound of the CI for the difference in the EASI 75 achievement rate between tralokinumab and dupilumab was within -10%.Conclusion: We conducted a MAIC analysis comparing tralokinumab and dupilumab based on EASI 75 achievement.The findings of this study show that tralokinumab is non-inferior to dupilumab and can be implemented in Korean clinical settings with a therapeutic position comparable to dupilumab.
Authors: Taekyung Kim, Keun Soo Shin, Hyojin Kim, Eugene Kim, Leejung Choi, Dong Hun Lee
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4386913489