Year: 2023
Type: article
Study design: Observational Study
Abstract: Lung cancer (LC) is the leading cause of cancer deaths, and chronic obstructive pulmonary disease (COPD) can increase LC risk. Metallomics may provide insights into both of these tobacco-related diseases and their shared etiology. We conducted an observational study of 191 human serum samples, including those of healthy controls, LC patients, COPD patients, and patients with both COPD and LC. We found 18 elements (V, Al, As, Mn, Co, Cu, Zn, Cd, Se, W, Mo, Sb, Pb, Tl, Cr, Mg, Ni, and U) in these samples. In addition, we evaluated the elemental profiles of COPD cases of varying severity. The ratios and associations between the elements were also studied as possible signatures of the diseases. COPD severity and LC have a significant impact on the elemental composition of human serum. The severity of COPD was found to reduce the serum concentrations of As, Cd, and Tl and increased the serum concentrations of Mn and Sb compared with healthy control samples, while LC was found to increase Al, As, Mn, and Pb concentrations. This study provides new insights into the effects of LC and COPD on the human serum elemental profile that will pave the way for the potential use of elements as biomarkers for diagnosis and prognosis. It also sheds light on the potential link between the two diseases, i.e., the evolution of COPD to LC.
Authors: Belén Callejón-Leblic, Saida Sánchez Espirilla, Carolina Gotera-Rivera, Rafael Santana, Isabel Díaz-Olivares, José M. Marín, Ciro Casanova Macario, Borja García Cosio, Antonia Fuster, Ingrid Solanes García, Juan P. de-Torres, Nuria Feu Collado, Carlos Cabrera Lopez, Carlos Amado Diago, Amparo Romero Plaza, Luis Alejandro Padrón Fraysse, Eduardo Márquez Martín, Margarita Marín Royo, Eva Balcells Vilarnau, Antonia Llunell Casanovas, Cristina Martínez González, Juan Bautista Galdíz Iturri, Celia Lacárcel Bautista, José Luis Gómez-Ariza, Antonio Pereira-Vega, Luis Seijo, José Luis López-Campos, Germán Peces-Barba, Tamara García-Barrera
Institutions: Universidad de Huelva, National University of Saint Anthony the Abbot in Cuzco, Instituto de Salud Carlos III, Fundación Andaluza Beturia para la Investigación en Salud, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón, Universidad de La Laguna, Hospital Universitario Nuestra Señora de Candelaria, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias, Health Research Institute of the Balearic Islands, Hospital Universitario Son Espases, Hospital Son Llatzer, Hospital de Sant Pau, Clinica Universidad de Navarra, Instituto Maimónides de Investigación Biomédica de Córdoba, Hospital Universitario Reina Sofía, Hospital Universitario de Gran Canaria Doctor Negrín, Marqués de Valdecilla University Hospital, Fundación Hospital Manacor, Hospital Juan Ramón Jiménez, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío, Hospital Del Mar, Hospital Terrassa, Hospital Universitario Central de Asturias, Hospital de Cruces, Centro de Investigación Biomédica en Red, Universidad de Sevilla
Language: English
Subfield: Health, Toxicology and Mutagenesis
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,780
OpenAlex ID: W4386934813