Work

Combined data-driven and mechanism-based approaches for human-intestinal-absorption prediction in the early drug-discovery stage

Year: 2023

Type: article

Abstract: To precisely predict the intestinal absorption ratio (Fa) at an early stage in the discovery, we combined a data-driven (using chemical structures) and mechanism-based approach (using gastrointestinal unified theoretical framework).

Source: Digital Discovery

DOI: 10.1039/d3dd00144j

Authors: Koichi Handa, Sakae Sugiyama, Michiharu Kageyama, Takeshi Iijima

Institutions: Teijin Pharma Limited (Japan), Teijin (Japan)

Language: English

Topic: Computational Drug Discovery Methods

Subfield: Drug Discovery

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Teijin Pharma

OpenAlex ID: W4386972707

FWCI: 0.783

Cites: 49

Cited by: 9

Related to: 10