Year: 2023
Type: book-chapter
Abstract: Various exogeneous and endogenous factors constantly cause damages in the biomolecules within a cell. For example, per day, 10,000–100,000 molecular lesions occur in DNA per cell. The molecule modifications that are formed disturb the structure and function of the affected molecules. The purpose of this chapter is to introduce the damages to biomolecules caused by radiation, the associated repair pathways, and the effect on the cellular function. Special interest lies on the damages induced to DNA, the carrier of the human genome, and the consequence to genomic integrity, cell death, and cell survival. Additionally, related effects regarding inflammation and immunity, epigenetic factors, and omics are discussed. The chapter concludes with an explanation of the molecular factors of cellular hyper-radiosensitivity and induced radiation resistance.
Source: Springer eBooks
Authors: Judith Reindl, Ana Margarida Abrantes, Vidhula Ahire, Omid Azimzadeh, Sarah Baatout, Ans Baeyens, Bjorn Baselet, Vinita Chauhan, Fabiana Da Pieve, Wendy Delbart, Caitlin Pria Dobney, Nina Frederike Jeppesen Edin, Martin Falk, Nicolas Foray, Agnès François, Sandrine Frelon, Udo S. Gaipl, Alexandros G. Georgakilas, Olivier Guipaud, Michael Hausmann, Anna Jelinek Michaelidesova, Munira Kadhim, Inês Alexandra Marques, Mirta Milic, Dhruti Mistry, Simone Moertl, Alegría Montoro, Elena Obrador, Ana Salomé Pires, Roel Quintens, Nicholas Rajan, Franz Rödel, Peter Rogan, Diana Savu, Giuseppe Schettino, Kevin Tabury, Georgia I. Terzoudi, Sotiria Triantopoulou, Kristina Viktorsson, Anne-Sophie Wozny
Institutions: Universität der Bundeswehr München, Universidade Politécnica de Coimbra, Centro de Investigação em Meio Ambiente Genética e Oncobiologia, University of Coimbra, Federal Office for Radiation Protection, Ghent University, Belgian Nuclear Research Centre, Health Canada, Royal Belgian Institute for Space Aeronomy, European Commission, European Research Council, University of Toronto, University of Oslo, Czech Academy of Sciences, Czech Academy of Sciences, Institute of Biophysics, Inserm, Centre Léon Bérard, Institut de Radioprotection et de Sûreté Nucléaire, Universitätsklinikum Erlangen, National Technical University of Athens, Heidelberg University, Czech Academy of Sciences, Nuclear Physics Institute, Czech Technical University in Prague, Oxford Brookes University, Institute for Medical Research and Occupational Health, Hospital Universitari i Politècnic La Fe, Universitat de València, Goethe University Frankfurt, Western University, Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering, National Physical Laboratory, University of South Carolina, National Centre of Scientific Research "Demokritos", Institute of Nuclear & Radiological Sciences and Technology, Energy & Safety, Karolinska Institutet, Lyon 1 Université, Centre National de la Recherche Scientifique, Hospices Civils de Lyon, Hôpital Lyon Sud, Institut de Physique des 2 Infinis de Lyon
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4386982522