EFSUMB Technical Review – Update 2023: Dynamic Contrast-Enhanced Ultrasound (DCE-CEUS) for the Quantification of Tumor Perfusion
Year: 2023
Type: article
Abstract: Dynamic contrast-enhanced ultrasound (DCE-US) is a technique to quantify tissue perfusion based on phase-specific enhancement after the injection of microbubble contrast agents for diagnostic ultrasound. The guidelines of the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) published in 2004 and updated in 2008, 2011, and 2020 focused on the use of contrast-enhanced ultrasound (CEUS), including essential technical requirements, training, investigational procedures and steps, guidance regarding image interpretation, established and recommended clinical indications, and safety considerations. However, the quantification of phase-specific enhancement patterns acquired with ultrasound contrast agents (UCAs) is not discussed here. The purpose of this EFSUMB Technical Review is to further establish a basis for the standardization of DCE-US focusing on treatment monitoring in oncology. It provides some recommendations and descriptions as to how to quantify dynamic ultrasound contrast enhancement, and technical explanations for the analysis of time-intensity curves (TICs). This update of the 2012 EFSUMB introduction to DCE-US includes clinical aspects for data collection, analysis, and interpretation that have emerged from recent studies. The current study not only aims to support future work in this research field but also to facilitate a transition to clinical routine use of DCE-US.
DOI: 10.1055/a-2157-2587
Institutions: Goethe University Frankfurt, Hirslanden Klinik Beau-Site, University Hospital Frankfurt, Hôpital Necker-Enfants Malades, Centre National de la Recherche Scientifique, Inserm, Université Paris Cité, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Laboratoire d’Imagerie Biomédicale, Tongji Hospital, Huazhong University of Science and Technology, XinHua Hospital, Haukeland University Hospital, University of Bergen, Krankenhaus Märkisch-Oderland, University Hospital Regensburg, Bracco (Germany), Charing Cross Hospital, Imperial College London, Commissariat à l'Énergie Atomique et aux Énergies Alternatives, Université Paris-Saclay, Laboratoire d'Imagerie Biomédicale Multimodale Paris-Saclay, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, University of Bologna
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
OpenAlex ID: W4387007399