Doublet or Triplet Antiemetic Prophylaxis for Nausea and Vomiting Induced by Trastuzumab Deruxtecan: an Open-Label, Randomized, and Multicenter Exploratory Phase 2 Study
Year: 2023
Type: article
Study design: Clinical Trial
Abstract: Background: Trastuzumab deruxtecan is classified as an anticancer agent that poses a moderate emetic risk in the international guidelines for antiemetic therapy.The guidelines recommend emesis prophylaxis using a two-drug combination therapy comprising a 5-hydroxytryptamine-3 receptor antagonist (5-HT3RA) and dexamethasone (DEX).However, the high incidence of nausea and vomiting associated with trastuzumab deruxtecan is problematic.The National Comprehensive Cancer Network guideline version 1.2023 classified trastuzumab deruxtecan as having a high risk of emesis and changed its recommendation to a triplet regimen including a neurokinin-1 receptor antagonist (NK1RA).However, the emetogenic potential of trastuzumab-deruxtecan and the optimal antiemetic prophylaxis are Ivyspring International
Source: Journal of Cancer
DOI: 10.7150/jca.87169
Authors: Hirotoshi Iihara, Mototsugu Shimokawa, Hiroko Bando, Yoshimi Niwa, Yutaka Mizuno, Yoshihiro Kawaguchi, Mika Kitahora, Akari Murakami, Masaaki Kawai, Kazushige Ishida, Makoto Takeuchi, Kazuhiro Ishihara, Tomokazu Iyoda, Takumi Nakada, Atsuko Ogiso, Yasuyuki Kojima, Fumiyoshi Kumagai, Aya Sawa, Ryutaro Mori, Kosuke Higuchi, Tomoko Furuta, Yoshiaki Kamei, Masami Tsuchiya, Azusa Terasaki, Senri Yamamoto, Mai Kitazawa, Mai Okazaki, Akio Suzuki, Manabu Futamura
Institutions: Gifu Pharmaceutical University, Gifu University Hospital, Yamaguchi University, National Hospital Organization Kyushu Cancer Center, University of Tsukuba, Yokkaichi Municipal Hospital, Asahi University Hospital, Ehime University Hospital, Yamagata University, Miyagi Prefectural Hospital Organization, Iwate Medical University, Gihoku Kosei Hospital, Fukushima Medical University Hospital, Gifu Municipal Hospital, Gifu Prefectural General Medical Center, St. Marianna University School of Medicine, Tohoku Rosai Hospital, University of Tsukuba Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,337
OpenAlex ID: W4387098533