Year: 2023
Type: article
Study design: Case Report
Abstract: Clasmatosis refers to cytoplasmic fragments in the peripheral blood (PB) or bone marrow We describe a clasmatosis of unusual morphology in the PB of an 83-year-old male with primary myelofibrosis diagnosed two years earlier according to the WHO criteria: megakaryocytic atypical hyperproliferation, JAK2-V617F positivity, absence of WHO criteria for other myeloid neoplasms, anaemia, and splenomegaly PB review showed RBCs anisopoichilocytosis, dysplastic neutrophilia (23.0x10 9 /L), and immature granulocytes (2.4x10 9 /L). Bone marrow aspiration gave "punctio sicca." Blast cells, NRBC, and micromegakaryocytes/megakaryoblasts were also observed (Figure Clasmatosis morphology displayed regular or irregular contours (Figure Small-medium clasmatosis originates from cytoplasmic budding and fragmentation (Figure Also, clasmatosis occurred after nuclear extrusion happened with the sequence in Figure Afterward, various cellular remnants can be observed: naked nuclei, denucleated cytoplasm, sometimes containing negative mold of the pre-existing nucleus, Cabotlike rings, and chromatin fragments. Entire cytoplasm or fragments have been observed retaining -after nuclear detachment -the content of previous phagocytosis (Figure
Source: Turkish Journal of Hematology
Institution: University of Bologna
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4387115757