Is pulmonary arterial hypertension associated with schistosomiasis distinct from pulmonary arterial hypertension associated with portal hypertension?
Year: 2023
Type: article
Abstract: Pulmonary arterial hypertension associated with schistosomiasis (SchPAH) and pulmonary arterial hypertension associated with portal hypertension (PoPAH) are lung diseases that develop in the presence of liver diseases. However, mechanistic pathways by which the underlying liver conditions and other drivers contribute to the development and progression of pulmonary arterial hypertension (PAH) are unclear for both etiologies. In turn, these unknowns limit certainty of strategies to prevent, diagnose, and reverse the resultant PAH. Here we consider specific mechanisms that contribute to SchPAH and PoPAH, identifying those that may be shared and those that appear to be unique to each etiology, in the hope that this exploration will both highlight known causal drivers and identify knowledge gaps appropriate for future research. Overall, the key pathophysiologic differences that we identify between SchPAH and PoPAH suggest that they are not variants of a single condition.
Source: JHLT Open
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
Funders: U.S. Department of Defense, American Heart Association, United Therapeutics Corporation, Cardiovascular Medical Research and Education Fund, Conselho Nacional de Desenvolvimento Científico e Tecnológico, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Allergy and Infectious Diseases
Awards: G3711034358, G4059873639, G4907670650, Complement Mediated Remodeling in Pulmonary Vascular Disease, Hif2-alpha stabilization in Interstitial Macrophages Causes Thrombospondin-1 Mediated Hypoxic Pulmonary Hypertension, THE PATHOBIOLOGICAL ROLE OF DYSREGULATED PULMONARY VASCULAR METABOLISM IN SYSTEMIC SCLEROSIS-ASSOCIATED PULMONARY ARTERIAL HYPERTENSION, Screening for schistosomiasis-associated pulmonary arterial hypertension, Activation, Phenotype and Function of CD4 T Cells in Schistosoma-Pulmonary Hypertension, Novel Role of Classical Dendritic Cells in the pathogenesis of Hypoxia-Induced Pulmonary Hypertension, The contribution of hypoxia inducible factor-1-dependent glycolysis in lung interstitial macrophages to the pathobiology of schistosomiasis-induced pulmonary hypertension.
OpenAlex ID: W4387327752