Work

Functionalization of Dodecaborates by Mild and Efficient Pd‐Catalyzed Formation of B−C Bonds with Boronic Acids**

Year: 2023

Type: article

Abstract: Hybrid organic‐inorganic molecules have recently received great interest due to their unique properties, which give access to their implementation in biological and material sciences. Herein, a new synthetic approach for the direct‐linkage of the purely inorganic dodecaborate cluster to organic building blocks through B−C bond is established, using boronic acids as functional groups on the organic moiety, reacting under Suzuki–Miyaura coupling conditions with iodo‐undecahydridododecaborate. The choices of ligand (DavePhos) and solvent (N‐methylpyrrolidone for electron‐poor, CD3CN for electron‐rich groups) are essential for the successful coupling. Ultimately, the newly described methodology is found to be functional‐group tolerant covering a wide spectrum of substrates including electron‐poor arenes.

Source: Chemistry - A European Journal

DOI: 10.1002/chem.202302466

Authors: Mahmoud K. Al‐Joumhawy, Jui‐Chi Chang, Khaleel I. Assaf, Bassem S. Bassil, Detlef Gabel

Institutions: Constructor University, Al-Balqa Applied University

Language: English

Topic: Boron Compounds in Chemistry

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $4,640

Funder: Deutsche Forschungsgemeinschaft