Year: 2023
Type: book-chapter
Abstract: Due to their biocompatibility, biodegradability, and distinctive bioactive features, polysaccharides have been identified as attractive candidates for a variety of biological applications in gene therapy and tissue engineering. Gene delivery is a method to relocate external DNA into the presenter cells for genetic research or gene remedy of human hereditary disorders. Gene therapy is one of the promising therapies for the management of various diseases like cancers; Alzheimer's viral infection as well as inherited diseases polysaccharides (carbohydrates) is usually isolated from plants and animal sources abundant in nature. For the delivery of genes, many polysaccharide-based biomaterials are being researched, including starch, cellulose, chitosan, dextran, and alginates. Further, these polymers are widely accepted by the body due to their biochemical similarity with human extracellular matrix components regulating cell signaling and tissue growth. Further, polysaccharides-based biomaterials are designed as graphene, metal oxide, and carbon nanotubes utilized in diverse fields of research. Recently, the major focus of research has been concentrating on the identification of the efficient and safe substitutes for the viral vehicles required in gene delivery. Future research can be expected to face significant hurdles related to understanding the molecular interactions of interacting compounds, the destiny of polysaccharide nanoparticles in vivo , and the molecular interactions between polysaccharides and loaded drugs/genes. The current chapter is primarily concerned with an over-view of polysaccharide-based biomaterials for a variety of biomedical applications, including gene transfer. Additionally, the focus will be on structure, cross-linking mechanisms, biosynthesis, chemical characteristics, biological properties, current problems, clinical usage, recent advancements, and methods to build polysaccharide-derived biomaterials. Finally, numerous future prospects for the design and fabrication of polysaccharides-based materials to accomplish their extensive commercial usage are discussed.
Source: Wiley eBooks
Institutions: Teerthanker Mahaveer University, Mahaveer University
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4387397481