Year: 2023
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: To determine the overall surgical outcomes of infranotch T4b oral cancers and compare them with T4a oral cancers. PubMed, EMBASE and Cochrane databases from 2000 to 2022 were systematically searched. Clinical studies reporting at least one outcome following curative surgery and adjuvant therapy for comparison of patients with either infranotch T4b (IN–T4b) or T4a tumour. The heterogeneity of the included studies was determined using Tau-squared, Chi-squared, and the Higgins I 2 test. The random effects model was used to determine the log odds ratio (logOR). The systematic review comprised 11,790 patients from 16 included studies. Seven studies were included in the meta-analysis ( n = 11,381). For IN–T4b patients, the pooled 2 and 5 year overall survival (OS) were 59.3% and 53.2%, 2 and 5 year disease-free survival (DFS) 57.9% and 48.4%, 2 and 5 year disease-specific survival (DSS) 72% and 68%, and 2 and 5 year local control (LC), 47% and 56%, respectively. There was no statistically significant difference in 2 year OS [logOR = 0.28 (−0.47, 1.03), p = 0.46, confidence interval (CI) = 95%], 5 year OS [logOR = 0.7 (−0.4, 1.8), p = 0.54, CI = 95%], 2 year DFS [logOR = 0.22 (−0.35, 0.79), p = 0.45, CI = 95%], 5 year DFS [logOR = 0.17 (−0.42, 0.77), p = 0.57, CI = 95%], 2 year LC [logOR = 0.47 (−0.33, 1.26), p = 0.25, CI = 95%] and 5 year LC [logOR = 0.34 (−0.31, 0.99), p = 0.31, CI = 95%] between IN–T4b and T4a oral cancers. Results of this meta-analysis suggest that IN–T4b oral cancers have similar outcomes to T4a oral cancers, which supports down-staging IN–T4b cancers to T4a cancers.
Source: Oncology and Therapy
Institutions: All India Institute of Medical Sciences Raipur, University of Helsinki, Helsinki University Hospital, AC Camargo Hospital, University of Michigan, Michigan Medicine, UCLouvain, University of Miami, Sylvester Comprehensive Cancer Center, KU Leuven, The University of Melbourne, La Trobe University, Austin Hospital, Olivia Newton-John Cancer Wellness & Research Centre, Austin Health, Monash University, The University of Texas MD Anderson Cancer Center, Louisiana State University Health Sciences Center Shreveport, University of Zielona Góra, Bar-Ilan University, Western Galilee Hospital
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $5,600
OpenAlex ID: W4387429477