Work

Relapsing Polychondritis following PD-1 Blockade by an Immune Checkpoint Inhibitor

Year: 2023

Type: article

Abstract: F-FDG uptake in reduced auricular lesions. On re-administration of pembrolizumab to maintain antitumor immunity, both auricles swelled again, and pembrolizumab was switched to paclitaxel, considering the risk of tracheobronchial chondritis. Although no recurrence of auricular chondritis was observed, the patient died from cancer progression 8 months after paclitaxel administration. RP can occur as a rheumatic irAE in patients receiving anti-PD-1 therapy, and a literature review with retrospective analysis indicates that PD-1 inhibition-induced RP is unusual and atypical.

Source: JMA Journal

DOI: 10.31662/jmaj.2023-0071

Authors: Tomoyuki Mutoh, Sonoko Chikamatsu, Takatsuna Sasaki, Hiroto Seino, Kazuhiro Sakamoto, Masataka Kudo

Institution: Osaki Citizen Hospital

Language: English

Topic: Otitis Media and Relapsing Polychondritis

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Japan Society for the Promotion of Science