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Management of transfusion-dependent β-thalassemia (TDT): Expert insights and practical overview from the Middle East

Year: 2023
Type: article
Abstract: β-Thalassemia is one of the most common monogenetic diseases worldwide, with a particularly high prevalence in the Middle East region. As such, we have developed long-standing experience with disease management and devising solutions to address challenges attributed to resource limitations. The region has also participated in the majority of clinical trials and development programs of iron chelators and more novel ineffective erythropoiesis-targeted therapy. In this review, we provide a practical overview of management for patients with transfusion-dependent β-thalassemia, primarily driven by such experiences, with the aim of transferring knowledge to colleagues in other regions facing similar challenges.
DOI: 10.1016/j.blre.2023.101138
Authors: Amal El-Beshlawy, Hany Dewedar, Salwa Hindawi, Salam Alkindi, Azza A. Tantawy, Mohamed A. Yassin, Ali T. Taher
Institutions: Cairo University, Latifa Hospital, King Abdulaziz University, Sultan Qaboos University Hospital, Ain Shams University, National Center for Cancer Care and Research, Hamad Medical Corporation, American University of Beirut Medical Center, American University of Beirut
Language: English
Subfield: Genetics
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,660
OpenAlex ID: W4387618865
FWCI: 5.275
Cites: 132
Cited by: 37
Related to: 10