Local Control Following Stereotactic Body Radiation Therapy for Liver Oligometastases: Lessons from a Quarter Century
Year: 2023
Type: review
Abstract: The utilization of stereotactic body radiation therapy for the treatment of liver metastasis has been widely studied and has demonstrated favorable local control outcomes. However, several predictive factors play a crucial role in the efficacy of stereotactic body radiation therapy, such as the number and size (volume) of metastatic liver lesions, the primary tumor site (histology), molecular biomarkers (e.g., KRAS and TP53 mutation), the use of systemic therapy prior to SBRT, the radiation dose, and the use of advanced technology and organ motion management during SBRT. These prognostic factors need to be considered when clinical trials are designed to evaluate the efficacy of SBRT for liver metastases.
Source: Current Oncology
Institutions: University of Toronto, Princess Margaret Cancer Centre, Dalhousie University, Nova Scotia Health Authority, Sunnybrook Health Science Centre, Odette Cancer Centre, Medical College of Wisconsin, The University of Texas Southwestern Medical Center, Odense University Hospital, University Medical Center Utrecht, The Christie Hospital, The Christie NHS Foundation Trust, King Hussein Cancer Center, GenesisCare, Fiona Stanley Hospital, Manipal Academy of Higher Education, Kasturba Medical College Hospital, Kasturba Medical College, Manipal, Universitätsklinikum Tübingen
Language: English
Subfield: Radiation
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,002
OpenAlex ID: W4387774191