Interactions between genetic risk for 21 neurodevelopmental and psychiatric disorders and sport activity on youth mental health
Year: 2023
Type: article
Abstract: Childhood is a sensitive period where behavioral disturbances, determined by genetics and environmental factors including sport activity, may emerge and impact risk of mental illness in adulthood. We aimed to determine if participation in sports can mitigate genetic risk for neurodevelopmental and psychiatric disorders in youth. We analyzed 4975 unrelated European youth (ages 9-10) from the Adolescent Brain Cognitive Development Study. Our outcomes were eight Child Behavior Checklist (CBCL) scores, measured annually. Polygenic risk scores (PRSs) were calculated for 21 disorders, and sport frequency and type were summarized. PRSs and sport variables were tested for main effects and interactions against CBCL outcomes using linear models. Cross-sectionally, PRSs for attention-deficit/hyperactivity disorder and major depressive disorder were associated with increases in multiple CBCL outcomes. Participation in non-contact or team sports, as well as more frequent sport participation reduced all cross-sectional CBCL outcomes, whereas involvement in contact sports increased attention problems and rule-breaking behavior. Interactions revealed that more frequent exercise was significantly associated with less rule breaking behavior in individuals with high genetic risk for obsessive compulsive disorder. Associations with longitudinal CBCL outcomes demonstrated weaker effects. We highlight the importance of genetic context when considering sports as an intervention for early life behavioural problems.
Source: Psychiatry Research
Authors: Melissa C Misztal, Earvin S Tio, Akshay Mohan, Daniel Felsky
Institutions: Centre for Addiction and Mental Health, University of Toronto
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,210
Funder: National Institute on Drug Abuse
Awards: G1058358382, G1436251778, G1510635755, G1586463187, G2735337927, G2998093352, G3305455594, G343603955, G3438786812, G3738900353, G4180929035, G4241744443, G469525291, G5002640097, G5976565686, G6983123888, G815084465, 9/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MICHIGAN, 17/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UCLA, 8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA, 6/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU, 21/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT WUSTL, 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB
OpenAlex ID: W4387817153