Year: 2023
Type: review
Abstract: Hypertension is the leading remediable risk factor for cardiovascular morbidity and mortality in the United States. Excess dietary salt consumption, which is a catalyst of hypertension, initiates an inflammatory cascade via activation of antigen-presenting cells (APCs). This pro-inflammatory response is driven primarily by sodium ions (Na+) transporting into APCs by the epithelial sodium channel (ENaC) and subsequent NADPH oxidase activation, leading to high levels of oxidative stress. Oxidative stress, a well-known catalyst for hypertension-related illness development, disturbs redox homeostasis, which ultimately promotes lipid peroxidation, isolevuglandin production and an inflammatory response. Natural medicinal compounds derived from organic materials that are characterized by their anti-inflammatory, anti-oxidative, and anti-mutagenic properties have recently gained traction amongst the pharmacology community due to their therapeutic effects. Flavonoids, a natural phenolic compound, have these therapeutic benefits and can potentially serve as anti-hypertensives. Flavones are a type of flavonoid that have increased anti-inflammatory effects that may allow them to act as therapeutic agents for hypertension, including diosmetin, which is able to induce significant arterial vasodilation in several different animal models. This review will focus on the activity of flavones to illuminate potential preventative and potential therapeutic mechanisms against hypertension.
Source: Biomedicines
Language: English
Subfield: Biochemistry
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,447
Funders: Vanderbilt University, Vanderbilt University Medical Center, Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Advancing Translational Sciences
Awards: G1221739687, Advancing drug repositioning and development for Alzheimer's Disease using functional genomics and computational phenomics, Functional heterogeneity of cardiac reparative cells after injury, G2615776415, Vanderbilt Hypertension and Blood Pressure Regulation Program, Vanderbilt Mouse Metabolic Phenotyping Center, G4410787187, G4424950377, Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seq, G9000052735, ENaC regulation and its role in blood pressure homeostasis, Immune Mechanisms of Salt-Sensitive hypertension, Vanderbilt Institute for Clinical and Translational Research (VICTR), Vanderbilt Diabetes Research Center, Anti-cytomegalovirus Immune Responses in Atherosclerotic Cardiovascular Disease in Persons Living with HIV
OpenAlex ID: W4387908077