Prospects for the Search and Development of New Original Pharmaceutical Substances - Derivatives of Usninic Acid Extracted From Lichens (review)
Year: 2023
Type: article
Abstract: Relevance: scientific and practical interest in usninic acid and its derivatives is increasing every year. This is due to their rather high biological activity, effectiveness in the treatment of many pathological conditions. In addition, usninic acid is contained in significant volumes in plant raw materials, primarily in ubiquitous lichens. The process of its extraction from plants is relatively simple and economically favorable. The purpose of the work was to conduct a narrative review of the prospects for the practical (pharmaceutical) use of usninic acid. Materials for research. For literature analysis, we performed search from the international databases Web of Science, Scopus, PubMed, as well as the domestic library system eLibrary. Results. Usnic acid in certain doses and combinations with other components has a toxic effect. These properties can be widely used in the treatment of infectious diseases (which is relevant due to the increasing resistance of microorganisms to drugs). Cytotoxic and genotoxic effects can be purposefully applied in the treatment of oncological neoplasms. The positive results of experimental studies, both in vitro and in vivo, proved the prospects for the development of new original pharmaceutical substances based on usninic acid derivatives obtained from lichens. It is concluded that lichens can be considered a unique natural supplier of biologically active components, primarily usninic acid. Its use is warranted for therapeutic and prophylactic purposes and requires the search and development of new pharmacological agents.
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4387934010