Year: 2023
Type: article
Abstract: Dysregulated lipid metabolism contributes to neurodegenerative pathologies and neurological decline in lysosomal storage disorders as well as more common neurodegenerative diseases. Niemann-Pick type A (NPA) is a fatal neurodegenerative lysosomal storage disease characterized by abnormal sphingomyelin accumulation in the endolysosomal lumen. The ability to monitor abnormalities in lipid homeostasis intracranially could improve basic investigations and the development of effective treatment strategies. We investigated the carbon nanotube-based detection of intracranial lipid content. We found that the near-infrared emission of a carbon nanotube-based lipid sensor responds to lipid accumulation in neuronal and in vivo models of NPA. The nanosensor detected lipid accumulation intracranially in an acid sphingomyelinase knockout mouse via noninvasive near-infrared spectroscopy. This work indicates a tool to improve drug development processes in NPA, other lysosomal storage diseases, and neurodegenerative diseases.
Source: Nano Letters
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Science Foundation, Joe W. and Dorothy Dorsett Brown Foundation, Ovarian Cancer Research Fund, Memorial Sloan-Kettering Cancer Center, Ovarian Cancer Research Alliance, Commonwealth Foundation for Cancer Research Foundation, Ara Parseghian Medical Research Fund, Break Through Cancer, Cycle for Survival, Emerson Collective, Expect Miracles Foundation, National Institutes of Health, National Cancer Institute, National Institute of Neurological Disorders and Stroke, Division of Chemical, Bioengineering, Environmental, and Transport Systems
Awards: Tumor-Selective Delivery Approaches for Medulloblastoma, G2051006376, G2377374449, G289723095, G4102770861, G4583515593, G5109122429, CAREER: A Quantitative Nanosensor to Measure Redox Potential in Living Systems, G6671297155, G8525765020, G9000003249, Cancer Center Support Grant, Inducing Neural Maturation in Medulloblastoma by Targeting EZH2, 1/2 CCNY-MSK Partnership for Cancer Research, Education and Community Outreach
OpenAlex ID: W4387970596