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Investigation of NO Role in Neural Tissue in Brain and Spinal Cord Injury

Year: 2023
Type: article
Abstract: Nitric oxide (NO) production in injured and intact brain regions was compared by EPR spectroscopy in a model of brain and spinal cord injury in Wistar rats. The precentral gyrus of the brain was injured, followed by the spinal cord at the level of the first lumbar vertebra. Seven days after brain injury, a reduction in NO content of 84% in injured brain regions and 66% in intact brain regions was found. The difference in NO production in injured and uninjured brain regions persisted 7 days after injury. The copper content in the brain remained unchanged one week after modeling of brain and spinal cord injury. The data obtained in the experiments help to explain the problems in the therapy of patients with combined brain injury.
Source: Molecules
DOI: 10.3390/molecules28217359
Authors: Viacheslav V Andrianov, Vladimir A Kulchitsky, Guzel G Yafarova, Lyeo V Bazan, Tatiana K Bogodvid, Irina B Deryabina, Lyudmila N Muranova, Dinara V Silantyeva, Almaz I Arslanov, Mikhail N Paveliev, Ekaterina Fedorova, Tatiana A Filipovich, Aleksei V Nagibov, Khalil Latypovich Gainutdinov
Institutions: Russian Academy of Sciences, Kazan Federal University, Kazan E. K. Zavoisky Physical-Technical Institute, National Academy of Sciences of Belarus, Institute of Physiology National Academy of Sciences of Belarus, Volga Region State Academy of Physical Culture, Sports and Tourism, University of Helsinki
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,558
OpenAlex ID: W4388048865
FWCI: 1.109
Cites: 102
Cited by: 7
Related to: 10