Human cytomegalovirus seropositivity is associated with reduced patient survival during sepsis
Year: 2023
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Sepsis is one of the leading causes of death. Treatment attempts targeting the immune response regularly fail in clinical trials. As HCMV latency can modulate the immune response and changes the immune cell composition, we hypothesized that HCMV serostatus affects mortality in sepsis patients. METHODS: We determined the HCMV serostatus (i.e., latency) of 410 prospectively enrolled patients of the multicenter SepsisDataNet.NRW study. Patients were recruited according to the SEPSIS-3 criteria and clinical data were recorded in an observational approach. We quantified 13 cytokines at Days 1, 4, and 8 after enrollment. Proteomics data were analyzed from the plasma samples of 171 patients. RESULTS: The 30-day mortality was higher in HCMV-seropositive patients than in seronegative sepsis patients (38% vs. 25%, respectively; p = 0.008; HR, 1.656; 95% CI 1.135-2.417). This effect was observed independent of age (p = 0.010; HR, 1.673; 95% CI 1.131-2.477). The predictive value on the outcome of the increased concentrations of IL-6 was present only in the seropositive cohort (30-day mortality, 63% vs. 24%; HR 3.250; 95% CI 2.075-5.090; p < 0.001) with no significant differences in serum concentrations of IL-6 between the two groups. Procalcitonin and IL-10 exhibited the same behavior and were predictive of the outcome only in HCMV-seropositive patients. CONCLUSION: We suggest that the predictive value of inflammation-associated biomarkers should be re-evaluated with regard to the HCMV serostatus. Targeting HCMV latency might open a new approach to selecting suitable patients for individualized treatment in sepsis.
Source: Critical Care
Authors: M. Unterberg, S. F. Ehrentraut, T. Bracht, A. Wolf, H. Haberl, A. von Busch, K. Rump, D. Ziehe, M. Bazzi, P. Thon, B. Sitek, K. Marcus, M. Bayer, K. Schork, M. Eisenacher, B. Ellger, D. Oswald, F. Wappler, J. Defosse, D. Henzler, T. Köhler, A. Zarbock, C. P. Putensen, J. C. Schewe, U. H. Frey, M. Anft, N. Babel, E. Steinmann, Y. Brüggemann, M. Trilling, A. Schlüter, H. Nowak, M. Adamzik, T. Rahmel, B. Koos
Institutions: Universitätsklinikum Knappschaftskrankenhaus Bochum, LWL-Universitätsklinikum Bochum, University Hospital Bonn, Ruhr University Bochum, Klinikum Westfalen (Germany), Witten/Herdecke University, Herford Hospital, University Hospital Münster, Universitätsklinik Marien Hospital Herne, University Hospitals of the Ruhr-University of Bochum, Essen University Hospital, University of Duisburg-Essen, Knappschaftskrankenhaus Recklinghausen
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,049
OpenAlex ID: W4388089356