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Carbon Nanomaterial-Based Hydrogels as Scaffolds in Tissue Engineering: A Comprehensive Review

Year: 2023
Type: review
Abstract: Carbon-based nanomaterials (CBNs) are a category of nanomaterials with various systems based on combinations of sp2 and sp3 hybridized carbon bonds, morphologies, and functional groups. CBNs can exhibit distinguished properties such as high mechanical strength, chemical stability, high electrical conductivity, and biocompatibility. These desirable physicochemical properties have triggered their uses in many fields, including biomedical applications. In this review, we specifically focus on applying CBNs as scaffolds in tissue engineering, a therapeutic approach whereby CBNs can act for the regeneration or replacement of damaged tissue. Here, an overview of the structures and properties of different CBNs will first be provided. We will then discuss state-of-the-art advancements of CBNs and hydrogels as scaffolds for regenerating various types of human tissues. Finally, a perspective of future potentials and challenges in this field will be presented. Since this is a very rapidly growing field, we expect that this review will promote interdisciplinary efforts in developing effective tissue regeneration scaffolds for clinical applications.
DOI: 10.2147/ijn.s436867
Authors: Thiago Stocco, Tianyi Zhang, Edgar Dimitrov, Anupama Ghosh, Alessandro da Silva, Wanessa Melo, Willian Tsumura, André Silva, Gustavo Sousa, Bartolomeu Viana, Mauricio Terrones, Anderson Oliveira Lobo
Institutions: Universidade Brasil, Pennsylvania State University, Pontifícia Universidade Católica do Rio de Janeiro, Center for Physical Sciences and Technology, Universidade Federal do Piauí, São Paulo State Technological College
Language: English
Subfield: Biomaterials
Open Access status: gold
Estimated APC paid: $2,836
OpenAlex ID: W4388190888
FWCI: 0.596
Cites: 322
Cited by: 38
Related to: 10