Year: 2023
Type: other
Abstract: Natural micronutrients, called polyphenols, serve as crucial physiological components in plants. They are a diverse family of compounds with one or more phenolic rings that are found in a variety of foods, including red wine, green tea, grapes, vegetables, and coffee. Most polyphenols are known to be strong antioxidants and they may have anti-inflammatory properties. The chemicals are touted as nutraceuticals having preventive efficacy in countering oxidant species over-genesis in normal cells, as well as the potential to arrest or treat oxidative stress-related illnesses. Pure (poly)phenols and/or their herbal/food complexes were discovered to have both antioxidant and pro-oxidant effects in this setting, implying a potential chemopreventive efficacy. Evidence supports their potential to induce apoptosis, growth arrest, DNA synthesis suppression, and/or signal transduction pathway regulation. Numerous studies have highlighted their potential in the prevention and treatment of a variety of clinical illnesses linked to inflammation and oxidative stress (e.g., cancer, cardiovascular, and neurodegenerative disorders). However, the poor stability, solubility, and bioavailability of these compounds make them difficult to employ simply, which restricts their utility and applications. Drug delivery system-based nanotechnologies are a promising approach to address these restrictions and improve the medicinal applications of polyphenols. Polysaccharide protein nanocarriers have recently been touted as having potential for encapsulating polyphenols. Still, there is uncertainty about the effectiveness of these nanoparticles formulated from polyphenols. Proper clinical trials and epidemiological studies are crucial for future utilization in medicine development. This chapter's major goal is to showcase new developments in nutraceuticals and polyphenol-based nanotechnology for use in pharmaceutical applications.
Source: Wiley eBooks
Institutions: DY Patil Deemed to be University, University of Manitoba
Language: English
Subfield: Biochemistry (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4388280667