Work

Environmental Enrichment Protects Against Decreased Expression of Hippocampal Synaptophysin and Gfap in Rats Exposed to Chronic Unpredictable Stress: the Role of Sex

Year: 2023

Type: article

Abstract: In the present study we explored the beneficial role of environmental enrichment (EE) against the negative outcomes of Chronic Unpredictable Stress (CUS) on astroglial and synaptic plasticity markers in male and female rats. Specifically, we studied possible alterations in hippocampal synaptophysin (SYN) and glial fibrillary acidic protein (GFAP) in CUS rats previously housed in EE. Adolescent Wistar rats were housed for 10 weeks either in enriched or standard housing (SH) conditions. On postnatal day 66, a subgroup from each housing condition was daily exposed to a 4-week CUS protocol (PND 66–95).

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2023.08.637

Authors: Evgenia Dandi, Paschalis Theotokis, Evangelia Spandou, Despina Tata

Institution: Aristotle University of Thessaloniki

Language: English

Topic: Stress Responses and Cortisol

Subfield: Behavioral Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500