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Interferon-gamma: a Master Cytokine in Astroglia-mediated Neuroprotection Against Oxaliplatin-induced Neurotoxicity in Organotypic Spinal Cord Slices

Year: 2023

Type: article

Abstract: Neurotoxicity is a common dose-limiting side effect of the anticancer drug oxaliplatin. Oxaliplatin-induced neuropathy, sustained by abnormal neuron-glia communications between the Peripheral Nervous System (PNS) and Central Nervous System (CNS), is mainly caused by hemichannels and gap-junction dysfunctions. During oxaliplatin-induced neuropathy, activated glial cells oversecrete pro-inflammatory cytokines, like IFN-γ, a crucial modulator of nervous responses. Recently, the RNA sequencing analysis of astrocytes collected from the CNS of oxaliplatin-treated animals, showed a dramatic deregulation of the IFN-γ pathway.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2023.08.367