Work

The Combinatorial Predegenerated Peripheral Nerve, Aldaynoglia Cells and Sulfoglycolipid Inhibitor Tol-51 Promote Axonal Regeneration and Locomotor Recovery.

Year: 2023

Type: article

Abstract: The recovery of the central nervous system after a spinal cord injury is limited by the low capacity for cell replacement and axonal growth due to inhibitory signals produced mainly by the degradation of myelin and the formation of a fibroglial scar, which prevents the reestablishment of functional connections. The use of predegenerated peripheral nerve (PN) transplants has been shown to favour axonal regeneration and growth of collateral emissions. In addition, the use of neural cells such as Aldynoglia presents a close glia-neuron interaction which favours a coating and growth of axons after spinal cord injury.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2023.08.245

Authors: Vinnitsa Buzoianu-Anguiano, Alejandro Arriero-Cabañero, Alfonso Fernandez-Mayoralas, Concepción García-Rama, Jörg Mey, Ernesto Doncel-Pérez

Institutions: Hospital Nacional de Parapléjicos, Consejo Superior de Investigaciones Científicas, Instituto de Química Orgánica General

Language: English

Topic: Nerve injury and regeneration

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500