Work

Deep Learning Applied to Live Imaging for Classifying Brain Organoids Derived From Neurodevelopmental Disorders Considering the Intrinsic Variability of the in Vitro Model

Year: 2023

Type: article

Abstract: Brain organoids are self-assembled in vitro 3D cell structures that recapitulate human brain development. In the last decade, brain organoids have risen as a powerful tool to study neurological disorders, including brain tumours and neurodevelopmental pathologies. However, brain organoids are intrinsically highly variable structures, thus limiting its use for obtaining reliable predictions of their phenotype and harnessing their scalability. Moreover, their analysis depends on highly trained human expertise and sophisticated technologies at endpoint.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2023.08.331