Work

Ketone Esters Partially Rescue Mitochondrial Bioenergetics After Acute Cervical Sci in Rats: a Time-course Study.

Year: 2023

Type: article

Abstract: Spinal Cord Injury (SCI) pathophysiology can be attributed to either primary physical injury or secondary injury cascades. Secondary Injury cascades lead to dysregulated metabolism and energetic deficits, which are directly linked to mitochondrial bioenergetics dysfunction. Neuroprotection and reduced oxidative stress are associated with improved cellular bioenergetics. In this regard, ketosis after traumatic brain injury (TBI), or after SCI has already been shown to improve secondary neuropathology by decreasing oxidative stress, increasing antioxidants, reducing inflammation, and improving mitochondrial bioenergetics.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2023.08.316