Drg Neurons Sensitization Is Induced by Altered Colon Organoids: a Novel in Vitro Model to Mimic Dysbiosis-associated Pain
Year: 2023
Type: article
Abstract: The mechanisms underlying the pathophysiology of visceral pain, in the context of inflammatory bowel diseases, are still debated. The impact of microbiota on intestinal epithelium is increasingly investigated, considering the involvement of epithelial cells in regulating neuronal signaling. With the aim of elucidating these mechanisms, colon organoids were used to model the complex physiology of intestinal epithelium in vitro and to study its functional response to normal or altered microbiota-derived products.
Source: IBRO Neuroscience Reports
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W4388364332