Work

Golexanolone Improves Peripheral Inflammation, Fatigue, Locomotor Gait, Motor Incoordination and Short-term Memory in Rats With Cholestasis and Hepatic Encephalopathy Due to Bile Duct Ligation

Year: 2023

Type: article

Abstract: Cholestasis may appear in patients with primary sclerosing cholangitis, primary biliary cholangitis, or drug-induced liver injury. Patients with cholestasis may show fatigue and other alterations that severely reduce their quality of life. Patients with liver disease may also show hepatic encephalopathy, with cognitive and motor impairment. Rats with bile-duct ligation (BDL) are a model both of cholestatic liver disease and of hepatic encephalopathy. There are no effective treatments for alterations such as fatigue or neurological impairment in liver diseases.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2023.08.338