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Mast Cells and Mast Cell Precursors Accumulate in the Pathogenic Alzheimer’s Disease Brain

Year: 2023
Type: article
Abstract: Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's, and Amyotrophic Lateral Sclerosis, have a high prevalence for which there are no effective treatments. Chronic neuroinflammation represents one of the most relevant pathological characteristics. Mast cells (MCs) are important in triggering chronic inflammation in the nervous system and in the glial-immune communication, releasing inflammatory mediators, neurotrophic factors, and proteases, and disrupting the blood-brain barrier.
Language: English
Subfield: Neurology
Open Access status: gold
Estimated APC paid: $1,500
OpenAlex ID: W4388366000
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