Year: 2023
Type: article
Abstract: We have established an effective one‐pot construction of arylcyanmides and o ‐halo arylcyanamides under metal‐free conditions with water at room temperature. Here we have used molecular iodine as a desulfurizing agent. During our standardization study, we could find the desired product in good yields using surfactant (1 % TPGS‐750‐M) and additive (NaOH). Library of aryl isothiocyanates readily converted into their respective desired products 2 a – j in 90–97 % yields. Similarly, o‐halo arylisothiocyanates carried out the reaction to give their respective halo cyanamides in good yields. Further, tetrazole compounds have also been constructed from cyanamides through click‐reaction under moderate reaction conditions.
Source: ChemistrySelect
Institutions: GITAM University, VIT-AP University
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4388573333