Work

Three-component domino reaction in Triton B: A facile synthesis of 4H-chromene derivatives

Year: 2023

Type: article

Abstract: Herein, we report an unprecedented one-pot domino synthesis of indole- or naphthol-tethered biologically relevant 4H-chromene derivatives from readily accessible salicylaldehydes, malononitrile, and indoles/β-naphthols employing efficient, inexpensive, non-metallic Benzyltrimethylammonium hydroxide (Triton B) as a base promoter. This protocol is an atom-economic three-component one-pot reaction that delivers various 4H-chromenes with good substrate scope and excellent yields. Moreover, this protocol compares the synthesis of 4H- chromene derivatives with the earlier reported 2H-chromenes avoiding the time and solvent-consuming tedious column chromatography.

Source: Results in Chemistry

DOI: 10.1016/j.rechem.2023.101215

Authors: Mrinal Talukdar, Nasreen Islam, Eeshwaraiah Begari

Institution: Central University of Gujarat

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,210

Funders: Department of Science and Technology, Ministry of Science and Technology, India, University Grants Commission