Work

Utility of Mycobacterium tuberculosis Genome Sequencing Snapshots to Assess Transmission Dynamics Over Time

Year: 2023

Type: article

Abstract: We explored the utility of brief Mycobacterium tuberculosis whole-genome sequencing (WGS) "snapshots" at a sentinel site within Lima, Peru, for evaluating local transmission dynamics over time. Within a 17-km2 area, 15 of 70 (21%) isolates with WGS collected during 2011-2012 and 22 of 81 (27%) collected during 2020-2021 were clustered (P = .414), and additional isolates clustered with those from outside the area. Isolates from the later period were disproportionately related to large historic clusters in Lima from the earlier period. WGS snapshots at a sentinel site may not be useful for monitoring transmission, but monitoring the persistence of large transmission clusters might be.

Source: The Journal of Infectious Diseases

DOI: 10.1093/infdis/jiad515

Authors: Courtney M Yuen, Chuan-Chin Huang, Ana Karina Millones, Roger I Calderon, Abigail L Manson, Judith Jimenez, Carmen Contreras, Ashlee M Earl, Mercedes C Becerra, Leonid Lecca, Megan B Murray

Institutions: Brigham and Women's Hospital, Harvard University, Broad Institute, Massachusetts Institute of Technology

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases, National Institute on Minority Health and Health Disparities

Awards: Advancing genomic, transcriptomic and functional approaches to combat globally important and emerging pathogens, Metabolic factors that control the spectrum of human tuberculosis, Epidemiology and transmission dynamics of MDR/XDR tuberculosis, Integrated discovery and development of innovative TB Diagnostics, Epidemiology of multidrug-resistant tuberculosis in Peru, New approaches to optimizing the application and measuring the impact of community-based tuberculosis interventions

OpenAlex ID: W4388928535

FWCI: 0.388

Cites: 14

Cited by: 2

Related to: 10