The effect of body mass index on maternal and perinatal outcomes in COVID‐19 infection during pregnancy and postpartum: Secondary analysis from the REBRACO cohort study
Year: 2023
Type: article
Abstract: OBJECTIVES: To compare maternal and perinatal outcomes among women with obesity, overweight, and normal body mass index, associated with COVID-19 infection during pregnancy and postpartum. METHOD: Prospective Cohort Study, within the REBRACO (Brazilian Network of COVID-19 in Pregnancy) multicenter initiative. Confirmed positive cases of SARS-CoV-2 were included, and women categorized into three groups according to their pre-pregnancy BMI: obesity (BMI ≥ 30), overweight (BMI <30 but >25), and normal BMI. Sociodemographic, clinical, and obstetric characteristics and different maternal and perinatal outcomes were compared, and a multiple regression analysis was performed to investigate factors independently associated with adverse maternal and perinatal outcomes. RESULTS: Two hundred eighty-nine women positive for SARS-CoV-2 infection were considered, and 202 had available data on maternal BMI for the current analysis. Overall, 72 (35.6%)obese, 68 (33.6%) overweight, and 60 (29.7%) normal BMI. Obesity was associated with increased adverse clinical outcomes including sepsis (P = 0.02), acute respiratory distress syndrome (P = 0.002), and the need for mechanical ventilation (P = 0.044). Considering perinatal outcomes, a multiple regression model confirmed obesity as an independent factor associated with adverse results (adjusted odds ratio 3.73, 95% CI 1.54-9.08). CONCLUSION: Obesity and overweight were associated with worse clinical outcomes, severe/critical COVID-19, and adverse perinatal outcomes.
DOI: 10.1002/ijgo.15250
Authors: Thais G. Sardinha, Giuliane J. Lajos, Renato T. Souza, Jose G. Cecatti, Adriana G. Luz, Maria Lúcia R. Oppermann, Rodolfo C. Pacagnella, Carolina C. Ribeiro‐Do‐Valle, Guilherme M. Nobrega, Thayna B. Griggio, Charles M. Charles, Carla Silveira, Maria J. Miele, Ricardo P. Tedesco, Karayna G. Fernandes, Sérgio Ha Martins‐Costa, Frederico Ja Peret, Francisco E. Feitosa, Evelyn Traina, Edson V. Cunha Filho, Janete Vettorazzi, Samira M. Haddad, Carla B. Candreucci, José P. Guida, Mario D. Correa Junior, Marcos Ab Dias, Leandro G. Oliveira, Elias F. Melo Junior, Marília Gq Da Luz, Maria Laura Costa, REBRACO Study Group
Institutions: Universidade Estadual de Campinas (UNICAMP), Hospital de Clínicas de Porto Alegre, Faculdade de Medicina de Jundiaí, Unimed Belo Horizonte, Universidade Federal do Ceará, Universidade Federal de São Paulo, Hospital Moinhos de Vento, Universidade Federal de São Carlos, Universidade Federal de Minas Gerais, Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira, Universidade Estadual Paulista (Unesp), Universidade Federal de Pernambuco
Language: English
Subfield: Obstetrics and Gynecology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: G1678908991
OpenAlex ID: W4389037313