Work

Long-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort study

Year: 2023

Type: article

Abstract: Participants and study designThis single-center, prospective, observational cohort study was performed on hospitalized COVID-19 patients in the period April 2020 to July 2021.The study population consisted of adults aged 18-65 years who were admitted to ABSTRACT INTRODUCTIONThe aim of our study was to investigate the long-term effects of different doses of steroid therapy given in the acute period in hospitalized coronavirus disease 2019 (COVID-19) patients.METHODS A total of 78 patients who were followed up in the hospital due to COVID-19 pneumonia and were discharged from the hospital more than 3 months ago, were included in our study.The patients were divided into 3 groups according to the steroid doses they received. RESULTSThe value of peak expiratory flow (PEF) was significantly lower in pulse-dose steroid group compared to high-dose steroid group (p=0.040).There was a significant difference in the values of carbon monoxide diffusion capacity (DLCO) and diffusion coefficient of alveolar volume (DLCO/VA) among all groups (p=0.027,p=0.048).The values of DLCO and DLCO/VA were significantly lower in the pulse-dose steroid group compared to the high-dose steroid group (p=0.022,p=0.049).The computed tomography (CT) score was significantly higher in the pulse-dose steroid group compared to both the nonsteroid group and high-dose steroid group (p=0.027,p=0.043).CONCLUSIONS Pulse-dose steroid therapy given in the acute period of COVID-19 pneumonia may negatively affect pulmonary function and recovery in the long-term.In addition, high-dose steroids were found to have a positive effect on pulmonary function compared to pulse-steroid therapy and nonsteroid therapy.

Source: Pneumon

DOI: 10.18332/pne/174604

Authors: Gokhan Karakurt, Hikmet Ucgun, Engin Aynaci, Mustafa Duger, Sukru E. Demir

Institutions: Atlas Üniversitesi, Beykent University, Istanbul Medipol University

Language: English

Topic: COVID-19 Clinical Research Studies

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,181