Geroprotector drugs and exercise: friends or foes on healthy longevity?

Year: 2023

Type: article

Abstract: Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotector drugs with exercise could extend healthy longevity beyond any individual treatment. However, the current dogma suggests that taking leading geroprotector drugs on the same day as exercise may limit several health benefits. Here, we review leading candidate geroprotector drugs and their interactions with exercise and highlight salient gaps in knowledge that need to be addressed to identify if geroprotector drugs can have a harmonious relationship with exercise.

Source: BMC Biology

DOI: 10.1186/s12915-023-01779-9

Authors: Christian J. Elliehausen, Rozalyn M. Anderson, Gary M. Diffee, Timothy W. Rhoads, Dudley W. Lamming, Troy A. Hornberger, Adam R. Konopka

Institutions: University of Wisconsin–Madison, William S. Middleton Memorial Veterans Hospital

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,290

Funders: U.S. Department of Veterans Affairs, American Federation for Aging Research, National Institutes of Health, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

OpenAlex ID: W4389473655