Year: 2023
Type: article
Abstract: A method has been proposed for the determination of drug containing amino group phenylephrine hydrochloride (PHP) in pharmaceutical dosage forms. The method is based on the ion pair reaction of this drug with reagent (egg yellow) in alkaline medium to give intense orange colored product (λmax at 470 nm of PHP) with molar absorptivity values of 1.67×105L.mol-1.cm-1 (r = 0.9995) and 5.60 ×105 L.mol-1.cm-1 (r = 0.9996), limit of detections of 0.0252 mg/L and 0.0236 mg/L and Limit of quantification of 0.0831 mg/L and 0.0708 mg/L respectively with concentration rang of (0.2-6.0) mg/L for drug. The experimental data underwent statistical analysis, which demonstrated the approaches' accuracy and precision. Excipients that are employed in pharmaceutical formulations as additives did not obstruct the suggested methods. Ion pairs are distinct chemical entities, electrically neutral, formed between ions of opposite charge and held together by Coulomb forces, without formation of a covalent bond.
Author: Dalia M. Jamil
Institution: Nahrain University
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4389577832