Effects of α-Humulene and its Nanoparticles in Experimental Model of Alzheimer's Disease: Behavioral Analysis and Anti-Inflammatory Activity
Year: 2023
Type: article
Abstract: The aim was to analyze the effects of α-humulene in experimental models of Alzheimer’s disease (AD). A sample composed of 33 rats, divided into the NC group: 3 animals, for analysis of normal tissue and behavior, PC: 10 animals submitted to induction of AD by application of β-amyloid, without treatment, HUM: 10 animals submitted to induction of AD and treated with α-humulene, and NHUM: 10 animals submitted to induction of AD and treated with α-humulene nanoparticles. Treatment was performed once daily for 14 days at a dose of 6.5µg, orally. The animals were submitted to behavioral tests of spatial memory and aversive memory, the cytokines TNF, IL-10, IL-2 and IL-4 were analyzed by flow cytometry. The treated animals obtained superior cognitive performance and expressed lower levels of inflammatory markers, with better results in the group with better results in the NHUM.
Authors: Maria Elvira Ribeiro Cordeiro, Luana Rodrigues Vasconcelos, Heron Bittencourt, Flávio Klinpovous Kerppers, Andressa Panegalli Hosni, Ivo Ilvan Kerppers, Rubiana Mara Mainardes, Christiane Schineider Machado Kolc, Ana Carolina Dorigoni Bini, Patricia Pacheco Tyski Suckow, Eliane Gonçalves de Jesus Fonseca, Angela Dubiela Julik
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4389625307