Comparison of Clinical and Genetic Characteristics Between Younger and Older Lung Cancer Patients
Year: 2023
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: The aim of this study was to analyze the clinical and genetic characteristics of young lung cancer cases, and to compare them with those of older cases. METHODS: We used the Thoracic Tumors Registry (TTR) as a data source representative of lung cancer cases diagnosed in Spain, and included all cases registered until 9/01/2023 which had information on age at diagnosis or the data needed to calculate it. We performed a descriptive statistical analysis and fitted logistic regressions to analyze how different characteristics influenced being a younger lung cancer patient. RESULTS: A total of 26,336 subjects were included. Lung cancer cases <50 years old had a higher probability of being women (OR: 1.38; 95% CI: 1.21-1.57), being in stage III or IV (OR: 1.32; 95% CI: 1.08-1.62), not having comorbidities (OR: 5.21; 95% CI: 4.59-5.91), presenting with symptoms at diagnosis (OR: 1.53; 95% CI: 1.29-1.81), and having ALK translocation (OR: 7.61; 95% CI: 1.25-46.32) and HER2 mutation (OR: 5.71; 95% CI: 1.34-24.33), compared with subjects ≥50 years. Among subjects <35 years old (n=61), our study observed a higher proportion of women (59.0% vs. 26.6%; p<0.001), never smokers (45.8% vs. 10.3%; p<0.001), no comorbidities (21.3% vs. 74.0%; p<0.001); ALK translocation (33.3% vs. 4.4%; p<0.001) and ROS1 mutation (14.3% vs. 2.3%; p=0.01), compared with subjects ≥35 years. CONCLUSIONS: Lung cancer displays differences by age at diagnosis which may have important implications for its clinical management.
Source: Archivos de Bronconeumología
Authors: Cristina Candal-Pedreira, Alberto Ruano-Ravina, Virginia Calvo de Juan, Manuel Cobo, José Manuel Trigo, Delvys Rodríguez-Abreu, Anna Estival, Enric Carcereny, Marc Cucurull, Rafael López Castro, Andrea Medina, Rosario García Campelo, Patricia Cordeiro González, Amparo Sánchez-Gastaldo, Joaquim Bosch-Barrera, Bartomeu Massutí, Manuel Dómine, Carlos Camps, Ana Laura Ortega, Alfredo Sánchez-Hernández, María Guirado Risueño, Edel del Barco Morillo, Alberto Garrido Fernández, Mariano Provencio
Institutions: Universidade de Santiago de Compostela, Instituto de Investigación Sanitaria de Santiago, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Hospital Universitario Puerta de Hierro Majadahonda, Hospital Clínico Universitario Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga, Institut Català d'Oncologia, Hospital Clínico Universitario de Valladolid, Universidade da Coruña, Complexo Hospitalario Universitario A Coruña, Hospital Universitario Virgen del Rocío, Hospital Universitari de Girona Doctor Josep Trueta, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital Universitario Fundación Jiménez Díaz, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Institut d'Investigació Biomèdica de Girona, Complejo Hospitalario de Jaén, Fundación Hospital Provincial de Castellón, Hospital General Universitario de Elche, Instituto de Investigación Biomédica de Salamanca
Language: Spanish
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,290
OpenAlex ID: W4389921283