Work

Direct thrombin inhibitors fail to reverse the negative effects of heparin on lung growth and function after murine left pneumonectomy

Year: 2023

Type: article

Abstract: Infants with pulmonary hypoplasia frequently require cardiopulmonary bypass and systemic anticoagulation. We investigate the effects of simultaneous exposure to heparin and direct thrombin inhibitors (DTIs) on lung growth and pulmonary function in a murine model of compensatory lung growth (CGL). Our data suggest that DTIs fail to reverse the inhibitory effects of subtherapeutic heparin on lung growth and function. Clinical studies on the impact of heparin with DTIs on clinical outcomes are thus warranted.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00096.2023

Authors: Savas T. Tsikis, Thomas I. Hirsch, Timothy Klouda, Scott C. Fligor, Amy Pan, Malachi M. Joiner, Sarah Z. Wang, Mikayla Quigley, Angela Devietro, Paul D. Mitchell, Hiroko Kishikawa, Ke Yuan, Mark Puder

Institutions: Boston Children's Hospital, Harvard University

Language: English

Topic: Neonatal Respiratory Health Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Beth Israel Deaconess Medical Center, Boston Children's Hospital, National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Harvard Longwood Research Training in Vascular Surgery, G388572957, A novel mouse model of Pulmonary Hypertension due to systemic Endothelial Cell Dysfunction, Boston Intellectual and Developmental Disabilities Research Center, G9000151253, Harvard Longwood Short-Term Research Training in Vascular Surgery, Research Training in Alimentary Tract Surgery

OpenAlex ID: W4389943995

FWCI: 0.519

Cites: 48

Cited by: 3

Related to: 10