Phase unwrapping for MHz optical coherence elastography and application to brain tumor tissue
Year: 2023
Type: article
Abstract: During neuro-oncologic surgery, phase-sensitive optical coherence elastography (OCE) can be valuable for distinguishing between healthy and diseased tissue. However, the phase unwrapping process required to retrieve the original phase signal is a challenging and critical task. To address this issue, we demonstrate a one-dimensional unwrapping algorithm that recovers the phase signal from a 3.2 MHz OCE system. With a processing time of approximately 0.11 s per frame on the GPU, multiple 2π wraps are detected and corrected. By utilizing this approach, exact and reproducible information on tissue deformation can be obtained with pixel accuracy over the entire acquisition time. Measurements of brain tumor-mimicking phantoms and human ex vivo brain tumor samples verified the algorithm's reliability. The tissue samples were subjected to a 200 ms short air pulse. A correlation with histological findings confirmed the algorithm's dependability.
Source: Biomedical Optics Express
DOI: 10.1364/boe.510020
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,913
Awards: G165400314, G2665553708, EXC 2167: Präzisionsmedizin für Chronische Entzündungserkrankungen (PMI), G4636467229, G5358301061, G6020826447, Verbundprojekt: Intraoperative Visualisierung von Hirntumoren in Echtzeit durch die optische Kohärenztomographie (Neuro-OCT) - Teilvorhaben: Live-3D-OCT-Systems mit angiographischer Darstellung, Verbundprojekt: Intraoperative Visualisierung von Hirntumoren in Echtzeit durch die optische Kohärenztomographie (Neuro-OCT) - Teilvorhaben: Adaption und klinische Evaluierung eines High Speed OCT-Systems
OpenAlex ID: W4390057581