Extended Postexposure Protection Against Vaginal Simian/Human Immunodeficiency Virus Infection With Tenofovir Alafenamide Fumarate/Elvitegravir Inserts in Macaques
Year: 2023
Type: article
Abstract: Vaginal inserts that can be used on demand before or after sex may be a desirable human immunodeficiency virus (HIV) prevention option for women. We recently showed that inserts containing tenofovir alafenamide fumarate (TAF, 20 mg) and elvitegravir (EVG, 16 mg) were highly protective against repeated simian/human immunodeficiency virus (SHIV) vaginal exposures when administered to macaques 4 hours before or after virus exposure (93% and 100%, respectively). Here, we show in the same macaque model that insert application 8 hours or 24 hours after exposure maintains high efficacy (94.4% and 77.2%, respectively). These data extend the protective window by TAF/EVG inserts and inform their clinical development for on-demand prophylaxis in women.
Authors: Natalia Makarova, Tyana Singletary, M Melissa Peet, James Mitchell, Shanon Bachman, Angela Holder, Chuong Dinh, Jonathan Lipscomb, Vivek Agrahari, Maria Mendoza, Yi Pan, Walid Heneine, Meredith R Clark, J Gerardo García-Lerma, Gustavo F Doncel, James M Smith
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,536
OpenAlex ID: W4390096401