AMYPAD: Correlation of Amyloid PET results with anxiety and depressive symptoms in SCD+, MCI and dementia patients
Year: 2023
Type: article
Study design: Observational Study
Abstract: Background Depression and anxiety are two frequent neuropsychiatric symptoms in Alzheimer’s disease (AD). Moreover, depressive symptoms and anxiety are frequently associated with greater amyloid deposition and risk of Alzheimer’s dementia. The aim of the present study is to assess the association between anxiety and depression and amyloid burden. Method In the AMPYAD study, participants with subjective cognitive decline (SCD+, n = 244), mild cognitive impairment (MCI, n = 341) and dementia (n = 255) were enrolled in eight European memory clinics between 2018 and 2020. They underwent three study visits (baseline, six months, thirteen months) with collection of cognitive data and symptoms of depression and anxiety (Hospital Anxiety and Depression Scale, HADS) as well as measures of quality of life and coping strategies. Amyloid burden was obtained as the standardized centiloid values (CL). Correlation analyses were carried out for HADS‐Scores and CL. We analyzed the progression of depressive and anxiety symptoms over time between patients with and without presence of amyloid (CL≥21) using mixed‐model‐ANOVA. All analyses were corrected for time of PET result disclosure. Result A total of 840 patients (46.2% female; mean age of 70.9 (SD = 7.8)) were included. Among SCD+ patients, CL values were positively correlated with baseline anxiety scores (r(216) = .14, p = .038). In contrast, MCI and dementia patients showed a negative correlation between CL and depressive symptoms (r(296) = ‐.16, p = .005; r(209) = ‐.23, p<.001). In SCD+, there was no significant interaction between time and CL status for anxiety (p = .512), but a significant main effect of time (F(2,302) = 3.4, p = .036, η² = .02), indicating a decline in anxiety symptoms over time. A trend indicated higher anxiety for amyloid positive participants, but the effect missed statistical significance (p = .068). For depressive symptoms, we found no main effects and no significant interaction of time and CL status. Conclusion The AMYPAD study contains a large amyloid‐PET data set of patients from eight European memory clinics. We observed an association of increased anxiety scores with amyloid load in SCD+, but reduced symptoms of depression with higher amyloid load in the MCI and dementia group. These findings and their longitudinal development over time will be put into a broader context of patient characteristics.
Source: Alzheimer s & Dementia
DOI: 10.1002/alz.078793
Authors: Philip Zeyen, Lena Sannemann, Claus Escher, Franziska Maier, Ayda Rostamzadeh, Alexander Drzezga, Kathrin Giehl, Gerard N Bischof, Merle C. Hönig, Daniele Altomare, Valentina Garibotto, Frederik Barkhof, Philip Scheltens, Bart N.M. van Berckel, Lyduine E. Collij, Jose Luis Molinuevo, Oriol Grau‐Rivera, Juan Domingo Gispert, Julien Delrieu, Pierre Payoux, Agneta K Nordberg, Irina Savitcheva, Zuzana Walker, Paul Edison, Jean‐François Demonet, Andrew W. Stephens, Rossella Gismondi, Gill Farrar, Giovanni B Frisoni, Frank Jessen
Institutions: University of Cologne, University Hospital Cologne, University of Bonn, University Hospital Bonn, Forschungszentrum Jülich, Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia, University of Brescia, University of Geneva, University Hospital of Geneva, Amsterdam University Medical Centers, University College London, Amsterdam UMC Location Vrije Universiteit Amsterdam, Lundbeck (Denmark), Pasqual Maragall Foundation, Barcelonaβeta Brain Research Center, Hospital Del Mar, Municipal Institute for Medical Research, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable, Hospital del Mar Research Institute, Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Université Toulouse III - Paul Sabatier, Inserm, Centre Hospitalier Universitaire de Toulouse, Centre d'Epidémiologie et de Recherche en santé des POPulations de Toulouse, Université de Toulouse, Toulouse NeuroImaging Center, Karolinska University Hospital, Karolinska Institutet, St. Margaret's Hospital, Imperial College London, Centre Hospitalier Universitaire Vaudois, German Center for Neurodegenerative Diseases, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4390193378