Year: 2023
Type: article
Abstract: Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive cognitive decline.While the accumulation of amyloid-beta (Aβ) plaques and neurofibrillary tangles containing hyperphosphorylated tau are the main pathological hallmarks of AD, the complex etiology of this disease remains unclear.However, emerging evidence suggests that gram-negative bacteria and their cell wall component, lipopolysaccharide (LPS), may play a role in AD pathogenesis.Gram-negative bacterial components have been found to associate with AD neuropathology and can induce Aβ aggregation, tau hyperphosphorylation, neuroinflammation, and neuronal cell death.This review summarizes current knowledge on the potential mechanisms linking gram-negative bacteria to AD, including disruption of the gut-brain axis, activation of innate immunity, and direct interactions with AD pathology.Elucidating the contribution of gram-negative bacteria to AD may reveal novel targets for preventative and therapeutic interventions.Nevertheless, further research is needed to establish causality between specific gram-negative bacteria and AD progression.
Institutions: University of Benghazi, University of Ajdabiya
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4390410941